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Surg Oncol Clin N Am. 2001 Apr;10(2):417-32, x-xi.

New functions of stromal proteases and their inhibitors in tumor progression.

Author information

1
Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie, Liege, Belgium.

Abstract

Acquisition of invasive metastatic potential through protease expression is a key event in tumor progression. In carcinomas, the production of metalloproteinases and serine proteinases is regulated by a cross talk between stromal cells and cancer cells. Paradoxically, high rather than low levels of their inhibitors predict poor survival of patients suffering from a variety of cancers. Recent observations suggest a much more complex role of these inhibitors in tumor progression than expected initially.

PMID:
11382595
[Indexed for MEDLINE]

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