Send to

Choose Destination
Surg Oncol Clin N Am. 2001 Apr;10(2):417-32, x-xi.

New functions of stromal proteases and their inhibitors in tumor progression.

Author information

Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie, Liege, Belgium.


Acquisition of invasive metastatic potential through protease expression is a key event in tumor progression. In carcinomas, the production of metalloproteinases and serine proteinases is regulated by a cross talk between stromal cells and cancer cells. Paradoxically, high rather than low levels of their inhibitors predict poor survival of patients suffering from a variety of cancers. Recent observations suggest a much more complex role of these inhibitors in tumor progression than expected initially.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center