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Salud Publica Mex. 2001 Mar-Apr;43(2):103-7.

[Impact of weekly administration of folic acid on folic acid blood levels].

[Article in Spanish]

Author information

1
Departamento de Patología, Unidad de Genética y Defectos Congénitos, Facultad de Medicina, Universidad Autónoma de Nuevo León (NL), Monterrey, NL, México. laurmart@ccr.dsi.uanl.mx

Abstract

OBJECTIVE:

To evaluate the effect of weekly administration of 5 mg. folic acid (FA) intake on folic acid blood levels.

MATERIAL AND METHODS:

This concurrent comparative study was conducted in 1998, in urban and rural areas of Nuevo Leon State, Mexico. The study population consisted of 74 women who delivered a child during 1997, 39 of whom had a child with a neural tube defect. Women were given 5 mg. of folic acid, weekly for 3 months. Blood levels of folic acid were determined by radioimmunoassay (RIA) at baseline, and a week after taking the last folic acid dose. Data are presented as means and standard deviations.

RESULTS:

Ninety per cent of the women had significantly increased folic acid intraerythrocytary blood levels. Red cell folate increased from 150.49 +/- 31.17 ng/ml to 184.21 +/- 35.53 ng/ml (p < 0.005). Plasma folate increased from 5.93 +/- 1.98 ng/ml a 7.03 +/- 2.5 ng/ml (p < 0.05). Eighty-two per cent of women reached intracellular levels above 160 ng/ml.

CONCLUSIONS:

The weekly administration of folic acid is a simple and efficient method that could be used to supplement this vitamin to low-income populations. The English version of this paper is available at: http://www.insp.mx/salud/index.html.

PMID:
11381838
[Indexed for MEDLINE]
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