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Int J Biochem Cell Biol. 2001 Jun;33(6):555-76.

Substance p.

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Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, Via Fossato Di Mortara 19, 44100, Ferrara, Italy.


This article provides a brief overview of the history of substance P from its discovery in the 1930s to the present day. The development of substance P receptor agonists and antagonists, and more recently the employment of transgenic mice, provide a framework to explore the functional role of substance P. Chronic inflammation and pain are associated with a number of diseases, and it has been proposed that substance P, released from primary afferent nerve endings play a role in these conditions. Recent developments with substance P antagonists have demonstrated the importance of substance P in several models of disease that span from asthma to chronic bronchitis; from cystitis, inflammatory bowel disease to migraine; emesis, depression, pain and seizures. Advancements in the knowledge of the role of substance P, its agonists and antagonists could provide clinical solutions for a variety of chronic inflammatory conditions.

[Indexed for MEDLINE]

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