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Bioorg Med Chem Lett. 2001 Jun 4;11(11):1451-4.

Inhibitors of the bacterial cell wall biosynthesis enzyme MurC.

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  • 1Chemistry, Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA.

Abstract

A series of phosphinate transition-state analogues of the L-alanine adding enzyme (MurC) of bacterial peptidoglycan biosynthesis was prepared and tested as inhibitors of the Escherichia coli enzyme. Compound 4 was identified as a potent inhibitor of MurC from Escherichia coli with an IC(50) of 49nM.

PMID:
11378375
[PubMed - indexed for MEDLINE]
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