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Curr Opin Genet Dev. 2001 Jun;11(3):287-92.

Insulin/IGF signalling and ageing: seeing the bigger picture.

Author information

1
Department of Biology, University College London, 4 Stephenson Way, NW1 2HE, London, UK. david.gems@ucl.ac.uk

Abstract

Although the underlying mechanisms of ageing are not understood, it is known that the longevity of the nematode Caenorhabditis elegans is modulated by an insulin/IGF-signalling pathway. The focus now is on how this pathway is regulated, how it controls nematode ageing, and how this relates to the ageing process in higher animals.

PMID:
11377965
DOI:
10.1016/s0959-437x(00)00192-1
[Indexed for MEDLINE]

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