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Trends Immunol. 2001 Jun;22(6):308-11.

Distinct types of T-cell help for the induction of a humoral immune response to Streptococcus pneumoniae.

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Uniformed Services University of the Health Services, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.


Studies have indicated that purified soluble polysaccharide antigens can elicit T cell-independent Ig responses in vivo, although these responses can be modulated by T cells in a noncognate manner. Relatively little is known, however, concerning the parameters that regulate polysaccharide-specific, as well as protein-specific, Ig isotype responses to an intact extracellular bacterium. Using the murine in vivo humoral response to intact Streptococcus pneumoniae as a model it can be shown that CD4+ T-cell receptor alphabeta+ T cells deliver help for both polysaccharide- and protein-specific Ig responses. However, these responses differ fundamentally in their mechanism of action.

[Indexed for MEDLINE]

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