Send to

Choose Destination
Microbes Infect. 2001 May;3(6):493-507.

Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells.

Author information

Department of Gastroenterology, The Royal Alexandra Hospital for Children, PO Box 3515, Parramatta 2124, Westmead NSW, Australia.


Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center