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Neurosci Lett. 2001 Jun 8;305(2):99-102.

Cerebral cortical blood flow during loss of consciousness induced by gravitational stress in rhesus monkeys.

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  • 1Institut de Médicine Aérospatiale du Service de Santé des Armées, Département de Physiologie Aérospatiale, BP 73, 91 223, Brétigny sur Orge, France.


We investigated the influence of +Gz acceleration (head-to-foot inertial forces) onset on cerebral cortical blood flow (CBF) of rhesus monkeys to study the mechanisms underlying +Gz-induced loss of consciousness (G-LOC). CBF was measured through a chronic cranial window by laser-Doppler flowmetry and electrodes in contact with the dura mater were used to detect G-LOC (suppression of the cortical electrical activity). The animals were centrifuged up to +12 Gz with different G-onset rate until G-LOC occurred. G-LOC was preceded by a 2-5 s decrease in CBF. At G-LOC detection, CBF was not related to G-onset rate (mean CBF change: -76 +/- 9% of control value). We conclude that G-LOC results from cerebral ischemia rather than from mechanical stresses applied to the brain.

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