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Dev Dyn. 2001 Jun;221(2):231-7.

Zebrafish E-cadherin: expression during early embryogenesis and regulation during brain development.

Author information

1
Department of Medicine, Indiana University Medical Center, 1220 South Drive, Indianapolis, IN 46202-5116, USA.

Abstract

Zebrafish E-cadherin (cdh1) cell adhesion molecule cDNAs were cloned. We investigated spatial and temporal expression of cdh1 during early embryogenesis. Expression was observed in blastomeres, the anterior mesoderm during gastrulation, and developing epithelial structures. In the developing nervous system, cdh1 was detected at the pharyngula stage (24 hpf) in the midbrain-hindbrain boundary (MHB). Developmental regulation of MHB formation involves wnt1 and pax2.1. wnt1 expression preceded cdh1 expression during MHB formation, and cdh1 expression in the MHB was dependent on normal development of this structure.

PMID:
11376490
DOI:
10.1002/dvdy.1132
[Indexed for MEDLINE]
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