Format

Send to

Choose Destination
See comment in PubMed Commons below
Rev Med Virol. 2001 May-Jun;11(3):149-56.

The cellular receptor for measles virus--elusive no more.

Author information

1
Department of Virology, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan. yyanagi@virology.med.kyushu-u.ac.jp

Abstract

The identity of the measles virus receptor has been controversial. Several years ago CD46 was identified as a cellular receptor for the Edmonston strain of measles virus, but most clinical isolates of measles virus, which are most efficiently isolated in the marmoset B cell line B95a, cannot grow in many CD46+ cell lines. Although some researchers attributed it to post-entry block in viral replication, others believed that there is a receptor other than CD46 for wild-type measles viruses. A new study showed that human signalling lymphocytic activation molecule (SLAM; also known as CDw150) is a cellular receptor for measles virus, including the Edmonston strain. SLAM is expressed on lymphocytes and dendritic cells, and plays an important role in lymphocyte activation. The identification of SLAM as a measles virus receptor nicely explains the pathogenesis of measles virus infection.

PMID:
11376478
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center