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Neurology. 2001 May 22;56(10):1409-12.

Cricopharyngeal achalasia is a common cause of dysphagia in patients with mtDNA deletions.

Author information

1
Department of Neurology, University of Bonn, Germany.

Abstract

To assess dysphagia, the authors examined 12 patients with Kearns-Sayre syndrome (KSS) or chronic progressive external ophthalmoplegia (CPEO) due to mitochondrial DNA (mtDNA) deletion by videofluoroscopy and manometry. Cricopharyngeal achalasia was documented in nine of 12 patients (75%), whereas deglutitive coordination problems were found in one patient. Cricopharyngeal myotomy may be an effective treatment in selected cases with severe cricopharyngeal obstruction.

PMID:
11376201
DOI:
10.1212/wnl.56.10.1409
[Indexed for MEDLINE]

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