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J Nat Prod. 2001 May;64(5):683-5.

Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.

Author information

1
College of Pharmacy, Seoul National University, Seoul, 151-742, Korea.

Abstract

Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.

PMID:
11374978
DOI:
10.1021/np000441w
[Indexed for MEDLINE]

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