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Z Kardiol. 2001;90 Suppl 3:38-42.

Transcriptional regulation of matrix gla protein.

Author information

1
Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Hospital (ACCI level 6), Hills Road, Cambridge CB2 2QQ, UK. aff24@cam.ac.uk

Abstract

Matrix Gla Protein (MGP) is a small protein which is thought to be an inhibitor of tissue calcification and a regulator of cell differentiation. In this study we have examined the transcriptional regulation of MGP within rat vascular smooth muscle cells (VSMCs). We found that MGP transcription is downregulated by retinoic acid and transforming growth factor beta (TGF beta) whereas it is upregulated by vitamin D3 and cyclic AMP.

PMID:
11374031
[Indexed for MEDLINE]

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