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J Antibiot (Tokyo). 2001 Mar;54(3):234-8.

Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554.

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1
Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.

Abstract

A novel compound, nafuredin, was isolated as an inhibitor of anaerobic electron transport (NADH-fumarate reductase). It was obtained from culture broth of Aspergillus niger FT-0554 isolated from a marine sponge. The structure was elucidated as an epoxy-delta-lactone with an attached methylated olefinic side chain on the basis of spectral analysis.

PMID:
11372780
DOI:
10.7164/antibiotics.54.234
[Indexed for MEDLINE]
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