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Eur J Clin Pharmacol. 2001 Apr;57(1):47-9.

High frequency of mutations related to impaired CYP2C9 metabolism in a Caucasian population.

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1
Department of Biochemistry, School of Biological Sciences, University of Extremadura, Avda. de Elvas s/n. 06071, Badajoz, Spain.

Abstract

OBJECTIVE:

To search for ethnic variability in the impact of cytochrome P450 2C9 (CYP2C9) polymorphism.

METHODS:

CYP2C9 allelic variants related to impaired CYP2C9 metabolism were analysed in genomic DNA from 157 Spanish healthy subjects using amplification-restriction and sequencing procedures.

RESULTS:

The frequency for CYP2C9 mutated alleles is higher among the Spanish subjects analysed than that reported for other Caucasian individuals: CYP2C9*2, 0.143 and CYP2C9*3, 0.162 (P = 0.0001). Nearly 10% of the individuals studied are expected to metabolise deficiently CYP2C9 substrates.

CONCLUSION:

In some Caucasian populations the impact of the CYP2C9 polymorphism may be much higher than that estimated from genotyping studies published to date.

PMID:
11372590
[Indexed for MEDLINE]
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