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Arch Biochem Biophys. 2001 May 1;389(1):84-93.

Oxidative stress, human genetic variation, and disease.

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1
Division of Biochemical Toxicology, Karolinska Institutet, Stockholm, Sweden.

Abstract

Oxidative stress has been implicated in numerous pathophysiological conditions and also aging. The tools for studying oxidative stress are now expanding as a result of the human genome effort and, in particular, expanding knowledge on human genetic variation. A few genetic variants, mostly in the form of single nucleotide polymorphisms of relevance to oxidative stress are already studied by a molecular epidemiologic approach. A review of the current knowledge on variant human genes that are directly implicated in human protection against oxidative stress is presented.

PMID:
11370676
DOI:
10.1006/abbi.2001.2295
[Indexed for MEDLINE]
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