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Curr Biol. 2001 May 1;11(9):R367-70.

DNA replication: building the perfect switch.

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1
ICRF Clare Hall Laboratories, South Mimms, EN6 3LD, UK. J.Diffley@icrf.icnet.uk

Abstract

A sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.

PMID:
11369250
[Indexed for MEDLINE]
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