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HIV Hotline. 1998 Mar;8(1):11.

Simplifying drug regimens.

[No authors listed]



In an attempt to simplify antiretroviral regimens, several studies evaluated the use of either indinavir or nelfinavir in twice-daily dosing regimens. Results from a study testing nelfinavir at 750 mg and 1250 mg dosing levels are presented indicating some success with twice-daily therapy, particularly at the 1250 mg level. The indinavir study also shows successful viral load drops using twice-daily regimens. A twice-daily regimen might be considered for patients unable or unwilling to adhere to the thrice-daily regimen. However, long term follow-up studies are needed before switching to twice-daily therapy.

[Indexed for MEDLINE]

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