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An interview with Anthony S. Fauci, MD. Interview by Mark Mascolini.



Dr. Anthony S. Fauci provides his thoughts on (1) HIV infection as a chronic yet manageable disease; (2) the use of triple combination therapy; (3) whether protease inhibitor combinations, such as AZT monotherapy, will prove to delay disease progression but not prolong survival; (4) the reliability of viral load numbers; (5) whether genetic markers will become clinical tools; (6) the immediate applications of second receptors for HIV and their interaction with beta-chemokines; (7) recommendations on using flu and pneumococcal vaccines in HIV-positive patients; (8) and his reasons for pursuing this work. Fauci cautiously believes HIV infection can eventually be converted into a manageable disease. He does not think enough is now known about viral load to make it a reliable monitoring tool for therapy. Genetic testing will be even more problematic than viral load measurements in assessing a person's risk of progression. Fauci also indicates that prompt antiretroviral therapy coupled with the immune response, provided the immune system was not damaged, might stop HIV progression. He also does not think there should be changes in the current recommendations for vaccination in HIV-positive patients. Worry about the seriousness of HIV and concern for mankind is his primary motivation to make the study of HIV his life's work.

[PubMed - indexed for MEDLINE]
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