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Posit Aware. 1996 Jan-Feb;7(1):5.

Thalidomide effective for oral ulcers.

[No authors listed]



A National Institutes of Health (NIH) study found that thalidomide heals oral aphthous ulcers in HIV-positive people. Severe mouth ulcers were healed in 14 of 23 patients receiving thalidomide compared to 1 of 22 patients receiving placebo. Patients received 200 mg thalidomide per day for 4 weeks. During the second maintenance phase of the study, all patients will receive open-label thalidomide in an attempt to determine the drug's ability to prevent the recurrence of ulcers in the mouth or esophagus. Patients suffering from esophageal ulcers will continue to be randomized to thalidomide or placebo because, due to the limited trial enrollment, the drug's effectiveness was undeterminable.

[Indexed for MEDLINE]

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