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Eur J Dermatol. 2001 May-Jun;11(3):203-8.

Unlikely role of Epstein-Barr virus in the pathogenesis of primary cutaneous CD30+ anaplastic large cell lymphoma.

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1
Department of Dermatology-Phlebology, University Hospital of Montpellier, Hôpital Saint-Eloi, 80, avenue Augustin-Fliche, 34295 Montpellier Cedex 5, France.

Abstract

BACKGROUND:

Primary cutaneous CD30+ anaplastic large cell lymphoma (ALCL) is a rare subset of cutaneous lymphoma, with a much better prognosis than its nodal counterpart. The pathogenesis of both nodal and primary cutaneous CD30+ ALCL is largely unknown but experimental data support the hypothesis that the Epstein-Barr virus could play a role in the nodal subset.

OBJECTIVE:

To evaluate the involvement of Epstein-Barr Virus (EBV) in primary cutaneous CD30+ ALCL by searching for both nucleic acids and EBV proteins in cutaneous lesions.

SETTING:

Two University Hospitals in Southern France (secondary referral hospitals).

PATIENTS:

Eight consecutive patients with typical primary cutaneous CD30+ anaplastic large cell lymphoma were studied.

METHODS:

Search for the presence of DNA, RNA and EBV proteins in cutaneous lesions by PCR, in situ hybridization and immunohistochemistry.

RESULTS:

EBV DNA and RNA was identified in only one lesion of primary cutaneous CD30+ ALCL and in none of the normal adjacent skin samples. In situ hybridization and immunohistological studies were consistently negative in all samples.

CONCLUSION:

These results do not support an early role of EBV in the oncogenetic pathogenesis of primary cutaneous CD30+ ALCL.

PMID:
11358725
[Indexed for MEDLINE]
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