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Biochem Soc Trans. 2001 May;29(Pt 2):345-50.

Role of reactive oxygen species in cell signalling pathways.

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1
Free Radical Research Group, Faculty of Applied Sciences, University of the West of England, Bristol, Coldharbour Lane, Bristol BS16 1QY, U.K. john.hancock@uwe.ac.uk

Abstract

Reactive oxygen species (ROS) were originally thought to only be released by phagocytic cells during their role in host defence. It is now clear that ROS have a cell signalling role in many biological systems, both in animals and in plants. ROS induce programmed cell death or necrosis, induce or suppress the expression of many genes, and activate cell signalling cascades, such as those involving mitogen-activated protein kinases.

PMID:
11356180
[Indexed for MEDLINE]
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