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Biochem Soc Trans. 2001 May;29(Pt 2):245-50.

Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux.

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Unit of Paediatric Surgery, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, U.K.


Carnitine palmitoyltransferase I is assumed to be rate limiting for beta-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit beta-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for beta-oxidation in the heart.

[Indexed for MEDLINE]

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