Format

Send to

Choose Destination
Bioorg Med Chem Lett. 2001 May 7;11(9):1157-60.

Quinazolines as cyclin dependent kinase inhibitors.

Author information

1
The DuPont Pharmaceuticals Company, Wilmington, DE 19880-0500, USA. thais.m.sielecki@dupontpharma.com

Abstract

Quinazolines have been identified as inhibitors of CDK4/D1 and CDK2/E. Aspects of the SAR were investigated using solution-phase, parallel synthesis. An X-ray crystal structure was obtained of quinazoline 51 bound in CDK2 and key interactions within the ATP binding pocket are defined.

PMID:
11354366
DOI:
10.1016/s0960-894x(01)00185-8
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center