Format

Send to

Choose Destination
See comment in PubMed Commons below
Antimicrob Agents Chemother. 2001 Jun;45(6):1930-3.

Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa.

Author information

1
Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.

Abstract

We report that 2 microg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.

PMID:
11353657
PMCID:
PMC90577
DOI:
10.1128/AAC.45.6.1930-1933.2001
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center