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Int Psychogeriatr. 2001 Mar;13(1):85-91.

Retrospective review of selective serotonin reuptake inhibitors and falling in older nursing home residents.

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  • 1Department of Psychiatry and Behavioral Neurosciences, Center for Healthcare Effectiveness Research, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.


We compared the rate of falling in older nursing home residents who had been prescribed selective serotonin reuptake inhibitors (SSRIs), other classes of antidepressants, and no antidepressants. Data were obtained from pharmacy records, medical records, fall logs, and incidence reports for one nursing home (1995 data). Older adults on SSRIs were more likely to fall than older adults not on antidepressants (p = .003) and were more likely to have an injurious fall (p = .03). The association with falling remained significant even when including potential confounders (p = .007). Older nursing home residents should be treated for depression. However, SSRIs may also carry an increased risk for falling.

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