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Traffic. 2001 May;2(5):297-302.

Clathrin function in yeast endocytosis.

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Department of Biology, The Johns Hopkins University, 3400 N. Charles St Baltimore, MD 21218, USA.


The process of endocytosis is a complex series of events involving the coordinated activity of many proteins. In animal cells, clathrin plays a vital role in the invagination of the plasma membrane leading to formation of vesicles during endocytosis. The study of endocytosis in yeast cells has been hindered by a debate about the role of clathrin in early internalization steps. This review summarizes the evidence for and against clathrin's involvement in internalization from the yeast plasma membrane.

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