Format

Send to

Choose Destination
Farmaco. 2001 Jan-Feb;56(1-2):81-5.

Microbial fermentation-derived inhibitors of efflux-pump-mediated drug resistance.

Author information

1
Microcide Pharmaceuticals, Inc., Mountain View, CA 94043, USA. mlee@microcide.com

Abstract

A library of 85000 microbial fermentation extracts was screened for inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa and Candida albicans. New compounds EA-371alpha and EA-371delta were isolated and demonstrated to be potent and specific inhibitors of the MexAB-OprM pump in P. aeruginosa. Two series of fungal metabolites, enniatins and beauvericins, were found to be ubiquitous and potent inhibitors of ABC transporters. Milbemycins were rediscovered as potent inhibitors of the CDRI pump in C. albicans, and demonstrated to potentiate effectively the antifungal activity of fluconazole and SCH-56592 against a wide variety of Candida clinical isolates.

PMID:
11347972
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center