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Transfusion. 2001 May;41(5):633-6.

Posttransfusion purpura secondary to an alloantibody reactive with HPA-5a (Br(b)).

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1
Rheumatology and Immunology Unit and the Vascular Medicine Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, NY, USA.

Abstract

BACKGROUND:

Posttransfusion purpura (PTP) is characterized by severe thrombocytopenia following blood transfusion that results from alloimmunization to platelet-specific alloantigens. Most cases involve antibodies against HPA-1a in homozygous HPA-1b persons.

CASE REPORT:

A patient developed PTP after cardiopulmonary bypass associated with a platelet-specific antibody with strong reactivity against HPA-5a (Br(b)). Geno-typing confirmed that the patient was homozygous for HPA-5b.

CONCLUSION:

This is the first well-documented occurrence of PTP associated with isolated allosensitization to HPA-5a or Br(b). The case highlights the importance of maintaining a high level of suspicion for PTP in the appropriate clinical setting, even in an atypical patient.

PMID:
11346699
[Indexed for MEDLINE]
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