Liposomal amphotericin B and surgery in the successful treatment of invasive pulmonary mucormycosis in a patient with acute T-lymphoblastic leukemia

M Björkholm; G Runarsson; F Celsing; M Kalin; B Petrini; P Engervall

doi:10.1080/003655401300077469

Liposomal amphotericin B and surgery in the successful treatment of invasive pulmonary mucormycosis in a patient with acute T-lymphoblastic leukemia

Scand J Infect Dis. 2001;33(4):316-9. doi: 10.1080/003655401300077469.

Authors

M Björkholm¹, G Runarsson, F Celsing, M Kalin, B Petrini, P Engervall

Affiliation

¹ Department of Medicine, Karolinska Hospital, Stockholm, Sweden.

PMID: 11345227
DOI: 10.1080/003655401300077469

Abstract

Pulmonary mucormycosis is a usually fatal opportunistic infection in immunocompromised patients. We describe the first case of an adult patient with hematological malignancy and profound neutropenia to survive a disseminated pulmonary Rhizomucor pusillus infection. Early diagnostic procedures combined with high doses of liposomal amphotericin B and surgical resection may have contributed to the successful outcome.

Publication types

Case Reports

MeSH terms

Amphotericin B / administration & dosage
Amphotericin B / therapeutic use*
Antifungal Agents / administration & dosage
Antifungal Agents / therapeutic use*
Combined Modality Therapy
Humans
Leukemia-Lymphoma, Adult T-Cell / complications*
Leukemia-Lymphoma, Adult T-Cell / diagnostic imaging
Liposomes
Lung Diseases, Fungal / complications
Lung Diseases, Fungal / diagnostic imaging
Lung Diseases, Fungal / therapy*
Male
Middle Aged
Mucormycosis / complications
Mucormycosis / diagnostic imaging
Mucormycosis / therapy*
Neutropenia / etiology
Pneumonectomy
Radiography
Rhizomucor*
Treatment Outcome

Substances

Antifungal Agents
Liposomes
Amphotericin B