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Isr Med Assoc J. 2000 Oct;2(10):787-9.

Feeding tolerance of ready-to-use versus powdered formulas in neonates.

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Department of Neonatology, Laniado Hospital, Sanz Medical Center, Netanya, Israel.



Following the introduction of ready-to-use formula in our neonatal department, we observed an increase in the number of neonates regurgitating after feeding.


To compare the feeding tolerance of neonates, in terms of regurgitations, to ready-to-use versus powdered formulas.


We compared the number of regurgitations in 727 healthy neonates after feeding ready-to-use formulas and powdered formulas of two different manufacturers. Six groups of neonates were formed, three for each manufacturer. Each of the two groups was fed with either ready-to-use formula or with reconstructed powdered formula (using a two-compartment patented feeding bottle called Twist 'N Feed) and one group received both preparations during 2 successive days.


The groups that were fed only with ready-to-use formulas had significantly more regurgitations than those fed with powdered formulas. Within the group that received both types of formulas there were significantly more regurgitations following the ready-to-use than the powdered formula.


Feeding tolerance, in terms of regurgitations, was significantly better in neonates fed reconstituted powdered formula as opposed to ready-to-use formulas. More studies are required to determine the exact mechanism for these differences.

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