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Trends Biochem Sci. 2001 May;26(5):304-10.

Receptor clustering and transmembrane signaling in T cells.

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  • 1Dept of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.


T cells are activated via engagement of their cell-surface receptors with molecules of the major histocompatibility complex (MHC) displayed on another cell surface. This process, which is a key step in the recognition of foreign antigens by the immune system, involves oligomerization of receptor components. Recent characterization of the T-cell response to soluble arrays of MHC-peptide complexes has provided insights into the triggering mechanism for T-cell activation.

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