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Trends Biochem Sci. 2001 May;26(5):273-5.

The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation.

Author information

1
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. aravind@ncbi.nlm.nih.gov

Abstract

Sequence profile analysis was used to detect a conserved globular domain in several proteins including deltex, Trip12 and poly-ADP-ribose polymerase homologs. It was named the WWE domain after its most conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP-ribose conjugation systems.

PMID:
11343911
DOI:
10.1016/s0968-0004(01)01787-x
[Indexed for MEDLINE]

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