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Curr Opin Cell Biol. 2001 Jun;13(3):338-43.

Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.

Author information

1
University of Cambridge, CRC Department of Oncology, The Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK. arv22@cam.ac.uk

Abstract

The BRCA2 tumour suppressor works in DNA recombination and repair pathways to preserve genome integrity. Recent progress provides fresh insights into its role as a regulator of the Rad51 recombination protein, underpinning a model in which BRCA2's involvement in chromosome stability and tumour suppression arises from its participation in recombinational processes essential for DNA replication.

PMID:
11343905
DOI:
10.1016/s0955-0674(00)00217-9
[Indexed for MEDLINE]

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