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Curr Opin Cell Biol. 2001 Jun;13(3):332-7.

Regulation and function of the p53 tumor suppressor protein.

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Regulation of Cell Growth Laboratory, Building 560, Room 22-96, National Cancer Institute at Frederick, Frederick, MD 21702, USA.


Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.

[Indexed for MEDLINE]

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