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Curr Opin Cell Biol. 2001 Jun;13(3):320-5.

mRNA turnover.

Author information

1
Wellcome Trust Centre for Cell Biology, ICMB, University of Edinburgh, Kings' Buildings, Edinburgh EH9 3JR, UK. pmitch@holyrood.ed.ac.uk

Abstract

Nuclear RNA-binding proteins can record pre-mRNA processing events in the structure of messenger ribonucleoprotein particles (mRNPs). During initial rounds of translation, the mature mRNP structure is established and is monitored by mRNA surveillance systems. Competition for the cap structure links translation and subsequent mRNA degradation, which may also involve multiple deadenylases.

PMID:
11343902
DOI:
10.1016/s0955-0674(00)00214-3
[Indexed for MEDLINE]

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