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Mutat Res. 2001 Feb 25;485(1):69-81.

Bryn Bridges and mutagenesis: exploring the intellectual space.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. gwalker@mit.edu

Abstract

The products of the SOS-regulated umuDC genes are required for most UV and chemical mutagenesis in Escherichia coli. Recently it has been recognized that UmuC is the founding member of a superfamily of novel DNA polymerases found in all three kingdoms of life. Key findings leading to these insights are reviewed, placing a particular emphasis on contributions made by Bryn Bridges and on his interest in the importance of interactions between the umuDC gene products and the replicative DNA polymerase.

PMID:
11341995
DOI:
10.1016/s0921-8777(00)00075-6
[Indexed for MEDLINE]

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