Format

Send to

Choose Destination
See comment in PubMed Commons below
Inflamm Res. 2001 Mar;50 Suppl 1:S30-4.

A comparison of the efficacy and tolerability of meloxicam and diclofenac in the treatment of patients with osteoarthritis of the lumbar spine.

Author information

1
CHU Trousseau, Service de Rhumatologie, Tours, France.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the efficacy and tolerability of meloxicam compared with diclofenac in patients with osteoarthritis of the lumbar spine.

SUBJECTS:

229 patients with radiologically confirmed osteoarthritis of the lumbar spine.

TREATMENT AND METHODS:

Once-daily meloxicam 7.5 mg tablet or diclofenac 100 mg slow release tablet. Efficacy and tolerability parameters were assessed at baseline and after 3, 7 and 14 days of treatment.

RESULTS:

The two drugs had equal short-term efficacy, with pain on motion of lumbar spine significantly (p<0.05) decreased at Day 3. Secondary efficacy variables were also significantly improved at Days 3, 7 and 14. There were no statistically significant differences between the two drugs, although the global tolerability of meloxicam was significantly better than for diclofenac, as assessed by the investigators (p = 0.0072) and the patients (p = 0.049).

CONCLUSIONS:

Meloxicam and diclofenac were equivalent in relieving the acute pain associated with osteoarthritis of the lumbar spine. However, meloxicam was much better tolerated.

PMID:
11339519
DOI:
10.1007/PL00000218
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center