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Eur J Gastroenterol Hepatol. 2001 Apr;13(4):377-82.

Gastric corpus atrophy following eradication of Helicobacter pylori.

Author information

1
Department of Medicine, Royal Victoria Hospital and Queen's University, Belfast, Northern Ireland.

Abstract

BACKGROUND:

Atrophic gastritis can develop in patients with Helicobacter pylori infection leading to a reduction in basal acid output. Whether the atrophy that develops is reversible is controversial.

OBJECTIVE:

To investigate the effect of H. pylori eradication in infected subjects who had developed atrophy of the corpus mucosa.

METHOD:

Ten H. pylori positive patients with corpus atrophy were identified at oesophagogastroduodenoscopy (OGD). They received eradication therapy with amoxicillin, clarithromycin and omeprazole. Repeat OGD with biopsy was performed at least 3 months later. Fasting plasma gastrin was measured at baseline and at re-endoscopy. H. pylori eradication was confirmed by 13C urea breath testing.

RESULTS:

Median time to re-endoscopy was 5 months. There was improvement in corpus atrophy in 50% of patients after H. pylori eradication, and a significant reduction in plasma gastrin (P = 0.03). The index patients had a significant diminution of basal acid output compared to controls.

CONCLUSION:

Corpus atrophy as defined by the Sydney System is reversible in some patients after H. pylori eradication. Improvement in atrophy is associated with a fall in fasting plasma gastrin levels. This may have implications in the prevention of gastric carcinoma.

[Indexed for MEDLINE]

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