Format

Send to

Choose Destination
Biochim Biophys Acta. 2001 Apr 23;1538(2-3):283-9.

Hyaluronan reduces migration and proliferation in CHO cells.

Author information

1
Institut für Physiologische Chemie und Pathobiochemie, Münster, Germany.

Abstract

Expression of the hyaluronan synthase gene in hyaluronan-deficient CHO cells changed the cell morphology from a spindle shape to a flattened epithelial-type form. Hyaluronan producing CHO cells showed reduced initial cell adhesion, migration, proliferation and density at contact inhibition, but no difference in random migration determined by the Boyden chamber assay. Addition of hyaluronan to the medium of CHO cells reduced migration, proliferation and initial cell adhesion. In contrast, coating the plastic dish with hyaluronan enhanced initial cell adhesion. These results are discussed in the context of the perplexing properties of hyaluronan on cellular functions.

PMID:
11336799
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center