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Mech Dev. 2001 May;103(1-2):197-200.

Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development.

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1
Abteilung Humangenetik, Universit├Ąt Ulm, D-89069 Ulm, Germany.

Abstract

Protein kinase C (PKC)-θ, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKCθ is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages.

PMID:
11335134
DOI:
10.1016/s0925-4773(01)00357-4
[Indexed for MEDLINE]
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