Send to

Choose Destination
Mech Dev. 2001 May;103(1-2):197-200.

Protein kinase C isoenzyme: selective expression pattern of protein kinase C-θ during mouse development.

Author information

Abteilung Humangenetik, Universit├Ąt Ulm, D-89069 Ulm, Germany.


Protein kinase C (PKC)-θ, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKCθ is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages.

[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center