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Microbes Infect. 2001 Apr;3(4):333-40.

Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia.

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  • 1Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56-787B, Cambridge, Massachusetts 02139, USA.


Here we review the history, clinical significance, pathology and molecular pathogenesis of Citrobacter rodentium, the causative agent of transmissible murine colonic hyperplasia. C. rodentium serves as an important model pathogen for investigating the mechanisms controlling attaching and effacing pathology, epithelial hyperproliferation, and tumor promotion in the distal colon of the mouse.

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