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Pol J Pharmacol. 2000 Nov-Dec;52(6):463-6.

Anxiolytic-like effects of group I metabotropic glutamate antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats.

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  • 1Institute of Pharmacology, Polish Academy of Sciences, Kraków.


We examined the anxiolytic-like activity of2-methyl-6-(phenylethynyl)-pyridine (MPEP) using the conflict drinking Vogel test in rats as a model. MPEP is a selective and brain-penetrable mGlu5 receptor antagonist, the most potent compound described so far. The results indicate that MPEP produced a dose-dependent anticonflict effect in rats. These data suggest that selective mGlu5 receptor antagonists may become a new class of anxiolytics.

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