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J Virol. 2001 Jun;75(11):5433-40.

Feline immunodeficiency virus cell entry.

Author information

1
Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.

Abstract

The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found to utilize the chemokine receptor CXCR4, but not CCR5, as a cellular receptor. Zidovudine blocked formation of late viral replication products most effectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by FIV.

PMID:
11333931
PMCID:
PMC114955
DOI:
10.1128/JVI.75.11.5433-5440.2001
[Indexed for MEDLINE]
Free PMC Article

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