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Int J Clin Pharmacol Ther. 2001 Apr;39(4):152-7.

Restitution of alpha-topography by piracetam in post-stroke aphasia.

Author information

1
Neurologische Universitätsklinik, Köln, Germany. b.szelies@pet.mpin-koeln.mpg.de

Abstract

OBJECTIVE:

Electroencephalographic and clinical effects of piracetam in post-stroke aphasia were evaluated in a prospective, randomized, double-blind, placebo-controlled trial.

METHODS:

In 24 patients with mild to moderate aphasia after ischemic stroke, quantitative topographic EEG at rest was studied before and after a 6-week treatment period.

RESULTS:

In the active treatment group, a significant shift in the alpha-rhythm from frontal to occipital regions was observed which may be due to a restitution of corticothalamic circuits involved in the generation of alpha-activity.

CONCLUSION:

Neuropsychological scores improved significantly and markedly in various domains of speech during piracetam treatment, whereas improvements were less marked and restricted to a few categories in the placebo group.

PMID:
11332870
[Indexed for MEDLINE]

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