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Nat Rev Mol Cell Biol. 2001 May;2(5):369-77.

Rap1 signalling: adhering to new models.

Author information

1
Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. j.l.bos@med.uu.nl

Abstract

Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1, the closest relative of Ras, has attracted much attention because of the possibility that it regulates Ras-mediated signalling. Rap1 is activated by extracellular signals through several regulatory proteins, and it might function in diverse processes, ranging from modulation of growth and differentiation to secretion, integrin-mediated cell adhesion and morphogenesis.

PMID:
11331911
DOI:
10.1038/35073073
[Indexed for MEDLINE]

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