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Nat Rev Mol Cell Biol. 2001 May;2(5):339-49.

Versatility of the mitochondrial protein import machinery.

Author information

1
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Hermann-Herder-Strasse 7, D-79104 Freiburg, Germany. pfanner@uni-freiburg.de

Abstract

The vast majority of mitochondrial proteins are synthesized in the cytosol and are imported into mitochondria by protein machineries located in the mitochondrial membranes. It has become clear that hydrophilic as well as hydrophobic preproteins use a common translocase in the outer mitochondrial membrane, but diverge to two distinct translocases in the inner membrane. The translocases are dynamic, high-molecular-weight complexes that have to provide specific means for the recognition of preproteins, channel formation and generation of import-driving forces.

PMID:
11331908
DOI:
10.1038/35073006
[Indexed for MEDLINE]
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