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Nat Rev Mol Cell Biol. 2001 May;2(5):327-38.

Back in the water: the return of the inositol phosphates.

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Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK.


Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.

[Indexed for MEDLINE]

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