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Nat Rev Genet. 2001 May;2(5):383-7.

The flexible genome.

Abstract

A principal assumption underlying contemporary genetic analysis is that the normal function of a gene can be inferred directly from its mutant phenotype. The interactivity among genes that is now being revealed calls this assumption into question and indicates that there might be considerable flexibility in the capacity of the genome to respond to diverse conditions. The reservoir for much of this flexibility resides in the nonspecificity and malleability of gene action.

PMID:
11331904
DOI:
10.1038/35072018
[Indexed for MEDLINE]
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