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Am J Psychiatry. 2001 May;158(5):805-7.

Sustained-release bupropion for selective serotonin reuptake inhibitor-induced sexual dysfunction: a randomized, double-blind, placebo-controlled, parallel-group study.

Author information

1
Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. givenss@upstate.edu

Abstract

OBJECTIVE:

The authors compared low-dose sustained-release bupropion with placebo for sexual dysfunction induced by selective serotonin reuptake inhibitors (SSRIs).

METHOD:

Thirty adults who had received SSRIs for at least 6 weeks, who were euthymic, and who had sexual dysfunction as determined by a total score greater than 19 out of a possible 30 on the Arizona Sexual Experience Scale were randomly assigned to receive either 150 mg/day of sustained-release bupropion or placebo at 6:00 p.m. for 3 weeks.

RESULTS:

There were no significant differences between the sustained-release bupropion and placebo groups as measured by change in Arizona Sexual Experiences Scale or Hamilton Depression Rating Scale scores or side effects.

CONCLUSIONS:

Future studies should compare higher doses of bupropion for treating sexual dysfunction and should include a greater number of subjects.

Comment in

PMID:
11329407
DOI:
10.1176/appi.ajp.158.5.805
[Indexed for MEDLINE]

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